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What Is Acomplia / Rimonabant / Zimulti?

Rimonabant, discovered and developed by French pharmaceutical company Sanofi-Synthelabo, is a new drug thas has shown great promise in trials for the treatment of obesity and related metabolic risk factors.

Rimonabant is already on the market in Europe, being sold under the trade name Acomplia, and is awaiting approval in the United States.The FDA would not permit rimonabant to be sold as Acomplia in the U.S., and Sanofi is now hoping to market it in the United States as Zimulti.

Rimonabant works by blocking the CB1 receptor, one of two receptors found in a newly described physiological system called the Endocannabinoid System (EC System), believed to play a critical role in the regulation of food intake and energy expenditure.

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The receptors are present on the surfaces of many cells throughout the body, including fat cells -- which are involved in lipid and glucose metabolism -- and those in the hypothalamus, the brain region that is thought to determine appetite.

Cannabinoids, chemical compounds produced by your body, latch on to the CB1 receptors, which are overactive in overweight and obese individuals, sending out a signal that prompts people to eat more.

Researchers wondered whether a drug that halted this action might curb appetite, and in 2001, the first animal study was conducted at the National Institute of Alcohol Abuse and Alcoholism in Bethesda, Md.

In the study, genetically altered mice that lacked cannabinoid receptors ate less than their litter mates, even after 18 hours of fasting. When the normal mice were given rimonabant, which blocked their CB1 receptors, the mice reduced their food intake.

In 2002, Sanofi-Synthelabo began human tests.

Acomplia works by selectively targeting and blocking the CB1 receptors, helping normalize the over-activation of the EC system and making hunger or cigarette pangs more manageable.

Much of the excitement about Acomplia stems from early results suggesting that the blocking of signals that control cravings not only facilitates weight loss, but that it also improves cardiovascular/ metabolic risk factors in overweight/obese patients.

In the RIO-Lipids trial, weight loss was accompanied by a decrease in waist size of 3.4 inches demonstrating a significant reduction in abdominal obesity, an independent marker for heart disease.

Dramatic improvements also were reported in lipid profile with a 23% increase in HDL-cholesterol (good cholesterol) and a 15% decrease in triglycerides.

Improvements in glucose tolerance and insulin levels were also reported. Approximately half of the patients diagnosed at the start of the study with metabolic syndrome, who received the higher 20 mg daily dose of Acomplia, no longer had this condition at the conclusion of the trial.

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How does Acomplia work?

Acomplia attacks and reduces a person’s urge or craving to eat more. Acomplia has the active ingredient Rimonabant which works directly on the Endocannabinoid system. This system affects energy balance, glucose and lipid metabolism in addition to weight in the human body. Rimonabant blocks certain receptors in this system known as cannabinoid receptors and thereby creates a feeling of false fullness in the person on Acomplia. As a result the person will eat less. When used in conjunction with a calorie reduced diet and regular exercise, Acomplia will lead to significant weight loss in obese patients.

How much weight can I lose by taking Acomplia?

Exhaustive clinical trials conducted with Acomplia on more than 6800 patients yielded substantial results. Patients given Acomplia for a period of one year achieved an average weight loss of six and half kg as compared to just over one and half kg achieved by those on placebo. Most of the weight loss was achieved in the first 9 months of the trial with Acomplia.

Acomplia was also found to reduce the risk of regaining weight. When a group of patients from one of the clinical trials was re-randomized and split into Acomplia and placebo groups, those patients who continued on Acomplia achieved a total weight loss of 7.5 kg over the two year trial period. On the other hand patients who were transferred to placebo achieved a much lower weight loss of only 3.1 kg over the same period.

The best part about Acomplia is that it brings about sizeable reduction in the waist circumference – nearly 6 to 7 cm on an average. This measure is an indication of intra-abdominal fat and is believed to be more important that BMI. If you have a large waist circumference, you should buy Acomplia for reducing it.

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